Nexera XS inert

Ultra High Performance Liquid Chromatograph

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Nexera XS Inert

Die mögliche Adsorption eines Analyten an benetzten Oberflächen von UHPLC-Instrumenten stellt einige kritische Herausforderungen bei der Analyse von Biomolekülen dar. Während für eine optimale chromatographische Trennung bei Verwendung von Säulen mit kleiner Partikelgröße eine erhöhte Drucktoleranz erforderlich ist, ist auch die Inertheit der benetzten Oberflächen sowie die Korrosionsbeständigkeit aufgrund der Verwendung mobiler Phasen mit hohen Salzkonzentrationen und extremen pH-Werten von größter Bedeutung . Das inerte System Nexera XS bietet die ideale Lösung für die Trennung von Biomolekülen, indem es die erhöhte Drucktoleranz eines UHPLC-Systems mit vollständiger Inertheit des Probenflusswegs kombiniert, was durch das Fehlen benetzter Metalloberflächen gewährleistet wird und eine extrem hohe Korrosionsbeständigkeit bietet.

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  • Nexera XS inert

    • Liquid Chromatography
    • Application Specific LC Systems

    The potential adsorption of an analyte onto wetted surfaces of UHPLC instruments poses some critical challenges when analyzing biomolecules. While elevated pressure tolerance is required to achieve optimal chromatographic separation through the use columns with a small particle size, the inertness of the wetted surfaces is also of the utmost importance as is resistance to corrosion due to the use of mobile phases with high salt concentrations and extreme pH values. The Nexera XS inert system offers the ideal solution for the separation of molecules by combining the elevated pressure tolerance of a UHPLC system with complete inertness of the sample flow path, ensured by the absence of wetted metal surfaces and offering ultra-high resistance to corrosion.

  • Nexera XS inert UHPLC: Clearly Higher Peaks for Bioanalysis

    • Liquid Chromatography

    This video provides an overview and description of the Nexera XS inert UHPLC, which combines the elevated pressure tolerance of a UHPLC system with complete inertness of the sample flow path, making it ideal for the analysis of biomolecules that adsorb to metal surfaces in liquid chromatography systems. Watch the video to learn about the key components of this system.

  • New Breakthrough in Biologics Analysis with Bioinert, Biocompatible and High-Pressure UHPLC

    • Liquid Chromatography

    Modern biotherapeutics, such as monoclonal antibodies (mAbs), antibody-drug conjugates (ADCs), and nucleic acid drugs provide new modalities to tackle persistent health concerns. To ensure patient safety and therapeutic quality, ICH-Q6B requires biological products to be tested for impurities and or separated during manufacturing process to determine the level of impurities present. Most of these analyses are performed using ultra-high performance liquid chromatography (UHPLC). Using small particles, acid, buffer solutions, organic solvents, and high salt concentrations in standard UHPLC systems can lead to corrosion, accelerated wear, and diminished performance. Analyzing biomolecules by UHPLC also poses some significant challenges due to the potential adsorption of analytes onto the wetted surfaces of the instrument, especially stainless steel materials like needles, tubing, and flow cells. The Nexera XS inert system offers a perfect solution for biopharmaceutical analytical method development, method scouting and quality control by incorporating the high-pressure tolerance of UHPLC alongside complete inertness of the sample flow path, which is achieved by eliminating wetted metal surfaces and offering an ultra-high corrosion resistance for SEC, IEX, and HIC chromatographic methods.

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